Based on literature Glycine max shows action on central nervous system and specially acts on glycine receptors, where glycine acts as an inhibitory neurotransmitter. The anticonvulsant effects of alcoholic and petroleum ether extracts of Glycine max in maximum electric shock in mice was tested. Glycine max (Soybean), dry seeds were collected, dried and coarsely powdered and latter was soxhelated using petroleum ether and absolute ethanol and air dried to obtain sticky dried extract. Four groups of male Swiss Albino mice (20-30 g) were used in this study. Group I animals received the normal saline for 10 days, Group II received standard drug phenytoin (25 mg/kg, p.o.) for 10 days, Group III animals received Glycine max alcoholic extract (50 mg/kg, p.o.) for 10 days, Group IV animals received Glycine max petroleum ether extract (50 mg/kg, p.o.) for 10 days. On 11th day the electroshock was delivered by using corneal electrodes. The intensity of stimulus was 50-100 mA, 50 Hz, for 0.2 sec. The animals were observed closely for 2 min and the parameters such as disappearance of the hind leg extensor, tonic convulsion was used as positive criterion. Percent of seizure inhibition relative to control was calculated. The Glycine max alcoholic and petroleum ether extracts significantly (P<0.01) decreased the extension phase and also the clonic convulsive phase, and showed protection in MES induced seizures when compared with phenytoin (p<0.01). The chronic administration of alcoholic as well as petroleum ether extracts significantly (P<0.01) increased the tissue glutathione and decreased the malondialdehyde and protein level in brain. In conclusion, both the extracts of Glycine max have shown potent anticonvulsant action in MES induced seizures.
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